Archive for the 'Advanced Level' Category

Installing Birdsuite – Not Fun.

Birdsuite is an application released by the Broad (Harvard/MIT) for analysing Affy SNP 6.0 array data. It was published in Nature Genetics. The installation process is really shockingly bad. Its a little surprising that journal like Nature Genetics can possibly justify publishing a piece of software in this condition. You would have to question whether [...]

Installing R, Rmpi & Bioconductor on Beowulf Cluster Running ClusterVision OS

We recently purchased a new computer cluster here and I was tasked with installing R & Rmpi on the thing. Not an especially easy task, so here’s how you do it.
Firstly we need to install R on the slave image. The slave image is basically a directory tree contained on the master node that the [...]

Performing Genome Wide Association (GWAS) using R and GenABEL

Note: This article is meant as a quickstart guide, there is ALOT to know about GWAS, but hopefully this provides a good starting point.
Introduction to GWAS
Genome Wide Association Studies (GWAS) are essentially a means by which to figure out which genetic traits (usually single nucleotide polymorphisms (SNPs)) are correlated with a variable of interest. In [...]